After he captures the essence of his subject so succinctly in his title, its a wonder that noted scientist Lewis Wolpert went on to write a whole book. Luckily for us, Malignant Sadness: The Anatomy of Depression lives up to its title, explaining the state of our knowledge and enlightening bystanders who have never been crippled by psychic pain about just what theyre mis After he captures the essence of his subject so succinctly in his title, its a wonder that noted scientist Lewis Wolpert went on to write a whole book. Luckily for us, Malignant Sadness: The Anatomy of Depression lives up to its title, explaining the state of our knowledge and enlightening bystanders who have never been crippled by psychic pain about just what theyre missing. Wolperts training as a developmental biologist helps him sift through the scientific literature, while his devastating episode of depression is the base of his eloquent descriptions of its subjective experience. Far from a deficit, his lack of psychiatric training allows him to explore more freely the unclear and ambiguous depths of our understanding of this all-too-common ailment. Given his background, one would expect Wolpert to emphasize biological causes and relief, but he gives psychological and environmental factors their due. As anyone with a debilitating disease will agree, any course of action promising recovery is worth pursuing, and Malignant Sadness carefully looks into many alternate explanations and therapies. Evolution, psychotherapy, Prozac and its ilk, and non-Western medicine all play roles in Wolperts drama, and his engaging prose keeps the reader intrigued throughout. Either you or someone close to you is practically certain to be struck by some form of depression during your lifetime--read Malignant Sadness and be prepared. --Rob Lightner