He was born Anthony Walter Patrick Hamilton in the Sussex village of Hassocks, near Brighton, to writer parents. Due to his fathers alcoholism and financial ineptitude, the family spent much of Hamiltons childhood living in boarding houses in Chiswick and Hove. His education was patchy, and ended just after his fifteenth birthday when his mother withdrew him from Westminster School.

After a brief career as an actor, he became a novelist in his early twenties with the publication of Monday Morning (1925), written when he was nineteen. Craven House (1926) and Twopence Coloured (1928) followed, but his first real success was the play Rope (1929, known as Ropes End in America).

The Midnight Bell (1929) is based upon Hamiltons falling in love with a prostitute, and was later published along with The Siege of Pleasure (1932) and The Plains of Cement (1934) as the semi-autobiographical trilogy 20,000 Streets Under the Sky (1935).

Hamilton disliked many aspects of modern life. He was disfigured badly when he was run over by a car in the late 1920s: the end of his novel Mr. Stimpson and Mr. Gorse (1953), with its vision of England smothered in metal beetles, reflects his loathing of the motor car. However, despite some distaste for the culture in which he operated, he was a popular contributor to it. His two most successful plays, Rope and Gas Light (1938, known as Angel Street in the USA), made Hamilton wealthy and were also successful as films: the British-made Gaslight (1940) and the 1944 American remake, and Alfred Hitchcocks Rope (1948).

Hangover Square (1941) is often judged his most accomplished work and still sells well in paperback, and is regarded by contemporary authors such as Iain Sinclair and Peter Ackroyd as an important part of the tradition of London novels. Set in Earls Court where Hamilton himself lived, it deals with both alcohol-drinking practices of the time and the underlying political context, such as the rise of fascism an